The EIF4F Complex: A Drug Target for Various Diseases (P16513)

Target Name: EIF4F translation-initiation complex

NCBI ID: P16513

EIF4F translation-initiation complex

Other Name(s): eIF4F complex | Eukaryotic Translation Initiation Factor 4 | EIF4F

The EIF4F Complex: A Drug Target for Various Diseases

The EIF4F translation-initiation complex (eIF4F complex) is a protein complex that plays a crucial role in the regulation of gene expression in eukaryotic cells. It is composed of four subunits: eIF4F, eIF4H, eIF4G, and eIF4J. The eIF4F subunit is the largest and contains the most abundant protein, while the eIF4H subunit is the least abundant.

The eIF4F complex is responsible for initiating the process of translation of mRNAs from the cytoplasm to the endoplasmic reticulum (ER). This process is critical for the delivery of proteins to various cell types and for the regulation of cellular signaling pathways.

The eIF4F complex functions by binding to specific sequences in the mRNAs that are being translated. This interaction between the eIF4F complex and the mRNAs allows the complex to initiate the process of translation by providing a structural framework for the start of the translation machinery.

One of the unique features of the eIF4F complex is its ability to translocate the initiation complex to the start of the mRNA. This process is critical for the efficient delivery of the initiation complex to the start of the mRNA and allows the complex to initiate the translation of the mRNA.

The eIF4F complex is also involved in the regulation of the stability of the initiation complex. This is achieved by the ability of the complex to bind to and translocate the eIF4G subunit. The eIF4G subunit is a key component of the initiation complex and is responsible for the stability of the complex.

The eIF4F complex is a drug target of interest in the study of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. The eIF4F complex has been shown to be involved in the regulation of cellular signaling pathways and has been linked to the development and progression of various diseases.

In conclusion, the EIF4F translation-initiation complex is a protein complex that plays a critical role in the regulation of gene expression in eukaryotic cells. Its role in the initiation of translation and the regulation of the stability of the complex makes it an attractive target for the development of new drugs and therapies for a variety of diseases. Further research is needed to fully understand the function of the eIF4F complex and its potential as a drug target.

Protein Name: EIF4F Translation-initiation Complex

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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